This webpage was produced as an assignment for Genetics 564, an undergraduate capstone course at the University of Wisconsin-Madison.
Protein Interaction Network
Protein-protein interactions are the foundation of cellular biology, underlying cell structure and function. They can be measured by yeast-two-hybrid or mass spectroscopy analyses, and can include measures of localization, abundance, turnover, and protein modifications.
Discussion
Understanding of protein-protein interactions are critical because they can provide understanding about the function of a protein. Additonally, protein interactions can change drastically between normal and diseased states. By understanding interactions, it is possible to discover new drugs intelligently and efficiently, thus unlocking the possibility of personalized medicine for specific abnormalities. For tuberin in particular, protein-protein interactions may be used to extend knowledge about its role at different stages of development and in different tissues by looking at the functions of interacting proteins. Furthermore, it may be interesting to study what happens to the interaction network of its most closely interacting proteins when it is knocked out.
|
References
[1] Larance M., Lamond A. I. (2015). Multidimensional proteomics for cell biology. Nat Rev Mol Cell Biol. 16(5):269-80. http://doi.org/10.1038/nrm3970.
Image References
Header: https://wallpaperscraft.com/image/web_clot_light_lines_neon_39033_1920x1200.jpg
Fig 1: http://www.nature.com/nrc/journal/v15/n3/images/nrc3891-f2.jpg
[1] Larance M., Lamond A. I. (2015). Multidimensional proteomics for cell biology. Nat Rev Mol Cell Biol. 16(5):269-80. http://doi.org/10.1038/nrm3970.
Image References
Header: https://wallpaperscraft.com/image/web_clot_light_lines_neon_39033_1920x1200.jpg
Fig 1: http://www.nature.com/nrc/journal/v15/n3/images/nrc3891-f2.jpg