This webpage was produced as an assignment for Genetics 564, an undergraduate capstone course at the University of Wisconsin-Madison.
Which model organism is most useful?
Model organisms are useful in modeling human conditions quickly, simply, inexpensively, and ethically.
Other methods include use of cancer cell lines and TSC patient data.
Other methods include use of cancer cell lines and TSC patient data.
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References
[1] Kobayashi, T., Minowa, O., Kuno, J., Mitani, H., Hino O., Noda, T. (1999). Renal Carcinogenesis, Hepatic Hemangiomatosis, and Embryonic Lethality Caused by a Germ-Line Tsc2 Mutation in Mice. Cancer Res, 59(6), 1206-1211.
[2] Drummond, I. A. (2004). Zebrafish kidney development. Methods in cell biology, 76, 501-530.
[3] Nakase Y, Fukuda K, Chikashige Y, Tsutsumi C (2006). A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex. Genetics 173(2):569-78. http://doi.org/10.1534/genetics.106.056895
[4] Delaney, M. A., Ward, J. M., Walsh, T. F., Chinnadurai, S. K., Kerns, K., Kinsel, M. J., Treuting, P. M. (2016). Initial Case Reports of Cancer in Naked Mole-rats (Heterocephalus glaber). Vet Pathol., 53(3), 691-6. http://doi.org/10.1177/0300985816630796
Image references,
Header: http://www.slate.com/content/dam/slate/articles/health_and_science/Science/2016/04/160405_SCI_Animal-Welfare-Act.jpg.CROP.promo-xlarge2.jpg
Sub-header: http://www.nature.com/nature/journal/v491/n7422/images/491031a-i1.0.jpg
[1] Kobayashi, T., Minowa, O., Kuno, J., Mitani, H., Hino O., Noda, T. (1999). Renal Carcinogenesis, Hepatic Hemangiomatosis, and Embryonic Lethality Caused by a Germ-Line Tsc2 Mutation in Mice. Cancer Res, 59(6), 1206-1211.
[2] Drummond, I. A. (2004). Zebrafish kidney development. Methods in cell biology, 76, 501-530.
[3] Nakase Y, Fukuda K, Chikashige Y, Tsutsumi C (2006). A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex. Genetics 173(2):569-78. http://doi.org/10.1534/genetics.106.056895
[4] Delaney, M. A., Ward, J. M., Walsh, T. F., Chinnadurai, S. K., Kerns, K., Kinsel, M. J., Treuting, P. M. (2016). Initial Case Reports of Cancer in Naked Mole-rats (Heterocephalus glaber). Vet Pathol., 53(3), 691-6. http://doi.org/10.1177/0300985816630796
Image references,
Header: http://www.slate.com/content/dam/slate/articles/health_and_science/Science/2016/04/160405_SCI_Animal-Welfare-Act.jpg.CROP.promo-xlarge2.jpg
Sub-header: http://www.nature.com/nature/journal/v491/n7422/images/491031a-i1.0.jpg